Endocrine Abstracts

Sarcoidosis is a multiorgan disease often affecting the lungs and lymphatic system. Neurological involvement occurs in sarcoidosis as granulomas infiltrate the nervous system. Here, we present a case of neurosarcoidosis diagnosed following non-specific neurological symptoms and delayed hypercalcaemia. A 32-year-old female presents with headaches, vomiting and acute confusion. During admission she developed unresponsive episodes. She has a background of type 1 diabetes and hypo...

A 91-year-old lady presented with bradycardia ‘HR ~36, she was alert and conscious initially. Soon after the initial assessment, she was found unresponsive; with blood glucose of 0.8 mmol/l; bradyapnoec; BP 151/59; GCS 5/15; temp ‘32.8°C’. She was aroused after resuscitation with intravenous Dextrose, GCS 15/15 with an element of confusion, the temperature did not exceed 34.9°C despite active warming. The patient looked in a low mood, barely audible, w...

Patients with neuroendocrine disease now have the option of having peptide receptor radionuclide therapy (PRRT) for both symptomatic treatment and reducing disease progression. Lutetium (177Lu) oxodotreotide is funded centrally in the UK and several sites have recently begun to provide the treatment for their patients. There are, however, several logistical, operational and regulatory obstacles which must be navigated to ensure the service is both safe and efficient...

Objective: Muslims worship by fasting from pre-dawn (suhoor) until sunset (iftar) for 30 days in the religious month of Ramadan. In addition to prolonged hunger, patients fasting with a diagnosis of hypothyroidism take their doses of levothyroxine outside of daytime fasting hours. This study compares thyroid functions of fasting hypothyroidism patients with the values before Ramadan.Methods: One hundred patients aged 18–65 years were included in the...

Aim: The aim was to assess the expressions of GLP-1, IGF-1 and leptin in the paraffin sections of operated thyroid cancer and non-thyroid cancer patients, and show the relationship of GLP-1, IGF-1 and leptin receptor expressions with thyroid cancer, comparatively.Materials and Methods: This study was carried out retrospectively. The case groups consisted of 20 medullary thyroid cancer (MTC), 20 follicular thyroid cancer (FTC), 20 classical papillary thyr...

Background: Neurotrophins are implicated in the physiology and pathophysiology of the mature gastrointestinal tract (GIT) such as motility and inflammatory bowel disease. Moreover, GIT disturbances has been attributed to hyperinsuliemia. Insulin-neurotrophins interactions in the (GIT) have not been investigated yet.Aim: To test the effect of Insulin on the expression of neurotrophins in the muscular wall of mice intestine and colon.<p class="abstext"...

Aim: Differentiated thyroid carcinomas (DTC) composes 95% of all thyroid malignancies originating from thyroid follicular epithelial cells. DTC expresses TSH receptors so long time TSH stimulation may cause cancer occurrence or malignancy progression. So we aimed to assess the role of TSH levels in predicting thyroid cancer stage or aggressiveness.Methods: We retsopectively searched thyroid cancer patients fort he last 10 years in our instution. Totally ...

Although the thyroid gland has an abundant blood supply, metastasis to the thyroid gland is a rare condition. Its incidence varies from 0.1% and 3% in clinical series. First case. A 56-year-old man presented to emergency service with neurological symptoms. CT of brain revealed multiple hyperdens lesions. Posteroanterior chest X-ray showed increased opacity in the left lung. Metastatic lung cancer was considered as a preliminary diagnosis and PET/CT was performed. PET/CT showed...

Heterophilic antibodies are well-known interferent factors affecting most immunoassays. However, they have been poorly evaluated in routine clinical practice. Definition of Subclinical Cushing’s Syndrome (SCs) has been arbitrary and prevalence has shown significant variations related with the diversity of the diagnostic tests. In most of the guidelines a low or suppressed corticothropin (ACTH) level has been suggested as an important predictor of SCs. Here, we sought to i...

Introduction: Adrenal incidentelomas are new era of the endocrinology. We aimed to see the results of adrenal masses retrospectively.Methods: Patients admitted to the Internal Medicine outpatient clinic for different complaints were retrospectively evaluated. Patients whom abdominal imaging like ultrasonography, magnetic resonance imaging or computed tomography were done and incedentally established adrenal masses were evaluated. Patients with a history ...